This concise, comprehensive book provides the most recent updates on rosacea management strategy, pathophysiology, genetic and environmental contribution, comorbidities, and other various topics. It meets the market need for a book that examines topics that are not typically included in rosacea textbooks. Beginning with a discussion on the current clinical understanding of the disease, this book reviews the aforementioned topics in a thorough yet accessible fashion. Complete with tables detailing a variety of drugs in an unbiased manner as well as color photos of real patients, each chapter aims to relay useful, practical information to dermatologists at every stage in their career. A valuable contribution to the Updates in Clinical Dermatology Series, Rosacea aims to promote the rapid and efficient transfer of medical research into clinical practice for the benefit practitioners and patients alike.
This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.
Dermatoanthropology of Ethnic Skin and Hair is a comprehensive text that extensively examines cutaneous disease in persons with skin of color. The breadth of knowledge in this book encompasses the wide scope of dermatologic disease with 26 distinct and unique chapters. It serves as a guide to the diagnosis and treatment of skin disorders for those populations with darker skin types.
Vashi and Maibach's Dermatoanthropology of Ethnic Skin and Hair provides an overview of medical, surgical, and cosmetic dermatology in addition to providing an extensive anthropological and basic science background to fully understand skin disorders in persons of color. Topics of discussion include anthropology of skin and hair, biophysical properties of ethnic skin, structure and function of the skin, physiologic pigmentation, mucosal lesions, acne, rosacea, inflammatory disorders, infections, autoimmune disorders, connective tissue disease, hyperpigmentation, hypopigmentation and depigmentation, keloids, scarring, pediatric disease, alopecias, adnexal disorders, common cosmetic concerns and treatments, and cultural considerations.
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods - both well established and recently introduced - in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists?.
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods - both well established and recently introduced - in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, and also students.?
Contact urticaria is an immediate but transient localized swelling and redness that occurs on the skin after direct contact with an offending substance. It is caused by a variety of compounds, such as foods, preservatives, fragrances, plant and animal products, metals, and rubber latex and the mechanism by which these provoke an immediate urticarial rash at the area of contact can be divided into two categories: non-immunological contact urticaria and immunological (allergic) contact urticaria. Non-immunological contact urticaria typically causes mild localized reactions that clear within hours, e.g. stinging nettle rash. This type of urticaria occurs without prior exposure of a patient's immune system to an allergen. Immunological contact urticaria occurs most commonly in atopic individuals (people who are prone to allergy). Hence prior exposure to an allergen is required for this type of contact urticaria to occur. While there have been other texts written on the subject over the last decade, this book is intended as an easily accessible guide for dermatologists and residents, as well as general practitioners, summarizing the most important concepts that will help physicians identify the signs and symptoms of Contact Urticaria Syndrome in their daily clinical practice. Each chapter is laid out in the following format: Concepts, Tools and Algorithms of Diagnosis and Management, a Clinical Case for each entry, and Recommendations. Additionally, the Volume Editors have worked to provide a global approach to this syndrome using internationally standardized requirements for diagnosis.
Irritant dermatitis is a common condition, accounting for a significant proportion of occupational skin disease. The recent advent of non-invasive skin bioengineering technology has accelerated dermatology research in this field. This book comprises an exhaustive reference text on irritant contact dermatitis, covering all aspects of the condition: clinical features, epidemiology, prevention and therapy, prognosis, mechanisms, pathology and regulatory issues. The book also presents novel in vitro and in vivo research techniques and findings. As irritant dermatitis affects multiple specialties, the audience for this book is wide, including clinical and investigative dermatologists, allergists, toxicologists, pharmaceutical scientists, occupational and environmental physicians, public health physicians, cosmetologists and skin bioengineers.
- Not only written by experts but the content of each of the chapters has also been peer-reviewed.
- Presents a step-by-step approach to the treatment of chronic wounds.
- For dermatologists, but also many other medical disciplines such as general practitioners and family physicians who also treat chronic wounds.
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods - both well established and recently introduced - in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.?
This book provides an up-to-date, compact but comprehensive review of chemical skin injuries, differentiating them from thermal skin burns. After an introductory chapter on the history of chemical skin injuries and the scope of the problem, the anatomy, histology, physiology, and immunology of normal skin are described. Mechanisms involved in chemical penetration of normal skin are explained, and the effects of damaged skin on chemical penetration are analyzed. The remainder of the book discusses a variety of clinically relevant aspects, such as the different forms of chemical skin injury, including injuries that arise during skin peeling or due to hair products; preventive measures; emergency treatment; rinsing therapy; medical and surgical treatment; and the importance of providing relevant information to workers. The role of predictive toxicology is also considered.
Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.
This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.
An era of global population aging is upon us. By 2030, one in eight people will be over age 65. Since women generally live longer than men, the health and welfare of postmenopausal women will become a significant public health concern. This book offers a comprehensive review of the life changes associated with menopause, both at the dermatological and physiological level (e.g., hormonal, immunological) and at the subcellular level. It critically examines the dermatological, biological, and clinical challenges to postmenopausal health and well-being and the current and emerging therapeutic interventions. The authors advocate a holistic approach, emphasizing the need to view the menopause as a life transition with various facets rather than as a series of distinct medical conditions to be managed. Our goal is to offer a comprehensive resource to the researchers, clinicians, physicians, and helping professions whose mission is to promote the health and well-being of women around the world.
Hand eczema is a major complaint worldwide and a frequent occupational disorder. This book provides a comprehensive and detailed overview of the classification, etiology, diagnosis, prevention, and therapy of hand eczema. It is innovative, up to date, and practical. The links with particular occupations are explained, the various diagnostic tests are presented, and the role of different topical and systemic treatments is clearly described. The authors are world leaders in the field. The "Textbook of Hand Eczema" reflects a new era in hand dermatitis and will be invaluable for all who deal with the condition in their clinical practice.
The fourth edition of this important book, which includes additional color illustrations, has been extensively revised, updated, and expanded to reflect the most recent developments. These include advances in patch testing methodology, in particular the new chambers that are appearing on the market, revision of the baseline series of patch tests to reflect the latest evidence-based work, and additional testing procedures. Other additions include sections on key allergens and concentrations, with the result is a superb guide to the current management of positive and negative patch test and prick test reactions that will be invaluable for all practicing dermatologists, from the beginner to the well-trained expert.
The fourth edition continues the tradition of partnering with the ICDRG (International Contact Dermatitis Research Group). The ICDRG was formed in 1966 to promote the understanding of contact dermatitis. It has had major roles in the standardization of patch testing and the facilitation of regular scientific meetings, for over forty years and thirty five years respectively. It has also been involved in the authorship of a number of publications on contact dermatitis. Both Drs. Maibach and Lachapelle are members and the ICDRG is now comprised of representatives from all over the world, and currently includes members from Belgium, Sweden, Denmark, the United Kingdom, USA, Germany, Singapore, Korea, India, Japan, Canada, Uruguay and Australia.
From the reviews of the previous editions:"The aim is to balance brevity and clarity with sufficient details for beginners in the field of diagnostic patch and prick testing. ... the book also will be of use to dermatology residents or anyone wishing to gain better knowledge of contact dermatitis. ... There are many high-quality photographs and useful algorithms and tables. ... It is clearly and concisely written and will serve as an indispensable guide for any dermatologist interested in contact dermatitis." (Renata H. Mullen, Doody's Review Service, August, 2009)
The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. However, some chemicals act directly on the skin including vesicants sulfur mustard and corrosive compounds such as strong acids or bases, and do not have to gain access to systemic circulation to cause extensive skin damage. Early and rapid skin decontamination is extremely important following exposure to chemical warfare agents and toxic industrial chemicals because it decreases serious skin damage to the patient and, potentially, their doctor.
This multi-authored international text pulls together a century of decontamination research and helps the reader expedite solutions that will decrease morbidity and mortality. Complete with dozens of hiqh quality photographs and illustrations, Skin Decontamination aids industrial hygiene, dermatology, occupational physicians and those involved in the public health arena.
Focusing on local wound care specifically for the dermatologist, this concise text provides a go-to source for practitioners looking for a quick solution for many of the most common wounds as well as an update on what's new in the field. From the most basic principles of local wound care to a look at what upcoming therapies like stem cells and lasers can do, this text is comprehensive and informed. Providing quality local wound care requires an ample knowledge of available products, their cost effectiveness, and the principles for the optimal interventions; Local Wound Care for Dermatologists includes these three guiding points in each chapter that focuses on a specific therapy. Expertly written text is accompanied by multiple tables of drug-specific names, current price points, and comparable products. Chapters include many color images, thereby providing insight to a given wound and the various therapies available to treat it. While the basics are reviewed in the opening chapters, later chapters feature updates in therapies including discussions on what's new in skin substitutes, negative pressure wound therapy, oxygen therapy, and an update in cell based therapy. Written with the dermatologist in mind, Local Wound Care for Dermatologists is an indispensable reference for students, residents, and practicing doctors alike. General practitioners and plastic surgeons will also find this title a useful refresher.
This book is written to help educate dermatologists and general physicians of the challenges involved in treating those with darker skin tones in culturally appropriate ways.
Distinctly broken up into three sections for ease of use, the reader enters the text through a series of chapters meant to introduce the physician to the anatomical structure and makeup of patient with skin of color as well as the evolution basic concepts for understanding and treatment. The second and longest section looks at diseases and cosmetic concerns covering some of the most common issues for patients with skin of color. The last section offers cultural considerations to treatment and care.
Socially conscious and comprehensive, Ethnic Skin and Hair is written by some of the leading names in dermatological treatment of skin of color, and functions as a concise and thorough tool for dermatologists at every stage in their career.