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Humana Press
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The hypothalamus is an anatomically small but functionally important part of the brain. In functional and pathophysiological terms, the hypothalamus represents the intersection of several areas of clinical and medical expertise. The human hypothalamus can be astutely referred to as the crossroad of endocrinology, psychiatry, neurology and neurosurgery. Because of its involvement in myriad physiologic functions and the varied ways disorders involving it can manifest, hypothalamic disease can initially come to medical attention in widely disparate settings and with widely different clinicians. Therefore, the detection and proper care of hypothalamic dysfunction and disease often requires carefully coordinated multidisciplinary care.
This volume fills a significant void in the medical professional community, comprehensively presenting the scope of hypothalamic structure, function, dysfunction and disease to cater to the various clinical, teaching and researchprofessionals that have a stake in this part of the human brain. This text captures in one place all the information that practicing clinicians, clinician scientists, and researchers need to be adequately informed about various aspects of the hypothalamus in all its complexity. It is comprehensive and broad in scope so that it provides relevant reference information for the wide range of professionals involved in the pre- and post-mortem detection, diagnosis, characterization, care and management of various hypothalamic disorders and diseases in addition to providing a sound anatomic and physiologic foundation of the normal human hypothalamus. The Human Hypothalamus can be used to differing degrees by medical professionals and students alike, finding utility for interested general clinicians, medical school and allied health professional teaching faculty as well as subspecialists in domains as wide as neurosurgery, neuroendocrinology, clinical psychiatry and neuro-oncology. -
This book illustrates the imperative for late-life depression prevention, introducing a broad range of approaches to prevention and provides detailed examples of clinical applications of late-life depression prevention - all with consideration of medical and scientific, social, economic and global health perspectives. Clear guidelines are delineated for assessing, treating and preventing such conditions as depression and anxiety, dementia, psychosis and mania, sleep disturbances and personality disorders. Written by experts in the field, this text considers the complicating conditions that depression may incur higher costs and create during the course and treatment of comorbid major medical conditions that are also highly prevalent in older adults - including diabetes, hypertension and heart disease.Prevention of Late-Life Depression: Current Clinical Challenges and Priorities is an important new volume that will be useful to all providers that are concerned with themental health of our rapidly expanding aged population.
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Hepatocellular cancer is the fifth most common cancer, with 600,000 new cases reported each year worldwide. Additionally, exciting changes in the science of HCC in the last four years have turned the practice of diagnosing and treating the disease upside down. In Hepatocellular Carcinoma: Diagnosis and Treatment, Second Edition, the leading experts in the field of HCC thoroughly update and expand upon the critically acclaimed first edition with all the latest developments in the diagnosis and treatment of primary liver cancer. The book details for physicians the diagnostic and therapeutic decision making process for dealing with such problems as incidental tumors in the liver transplant, the role of neo-adjuvant chemotherapy, intra-arterial vs intravenous therapy, the uses of embolization, and the significance of portal vein thrombus. New chapters discuss the introduction into clinical practice of cell cycle growth inhibitors, an expanded knowledge of Genomics and Proteomics, and novel ways of delivering intra-hepatic chemotherapy. This cutting-edge text is a vital resource and must have for today's hepatologists and medical and surgical oncologists.
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Integrative Therapies in Lung Health and Sleep
Linda Chlan, Marshall I. Hertz
- Humana Press
- 7 Janvier 2012
- 9781617795794
Integrative Therapies in Lung Health and Sleep provides an overview of integrative therapies to assist clinicians caring for patients with acute or chronic lung diseases and sleep disorders--emphasizing the scientific bases for these therapies; and their implementation into clinical practice. This volume focuses on complementary and alternative medicine (CAM) treatments, modalities, and practices that are integrated with conventional medical treatment and for which there is some evidence of safety and efficacy. Whole Medical Systems, with a specific focus on Traditional Chinese Medicine , are also addressed. Individual chapters are devoted to specific health conditions or illnesses, addressing the current state of the science in the four organizing CAM domains, including available information regarding benefits, risks, or safety considerations. Unique aspects of this volume are the chapters related to evaluation of the evidence base for integrative therapies; new animal model research with herbal preparations focused on the serious problem of sepsis in the ICU; guidance for counseling patients with chronic lung illnesses who may be desperate for a cure; and palliative and end-of-life care for patients with chronic lung conditions. Clinicians in various health care settings will find Integrative Therapies in Lung Health and Sleep beneficial in their practice, particularly as the use of integrative therapies becomes more widespread.
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Mediterranean Diet
Donato F. Romagnolo, Ornella I. Selmin
- Humana Press
- 29 Février 2016
- 9783319279695
This text is an especially timely new text as the number of studies focusing on the impact of the Mediterranean diet on disease prevention increases every year. The fundamental question addressed in this text is how food components and behavior of the Mediterranean diet reduce the risk of chronic diseases. In-depth chapters provide an overview of preclinical and clinical studies on Mediterranean dietary patterns, food components and lifestyle and their impact on health and disease. Large-scale "omic" approaches are highlighted to educate the reader about the molecular mechanisms through which specific components of the Mediterranean diet improves health and the opportunities and challenges for translating into practice the food recommendations of the Mediterranean pyramid. The volume concludes with information about the nutritional adequacy of Mediterranean foods and provides selected recipes. Mediterranean Diet: Impact on Health and Disease will be of great interest to students, clinicians, and scientists engaged in promoting health through nutrition and physical activity.
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Biological warfare has, unfortunately, in the post 9/11 world become a significant topic of discussion in both the medical and lay presses. In the wake of the biological "letter bombs" containing anthrax spores, the possibility of biologic and/or toxic attacks on civilians in any part of the world became no longer a possibility. It is now part of common discussion and consciousness.
This book presents the history of the topics and clinically relevant discussions on those high risk (Category A) diseases beyond anthrax as well as a number of infections and toxins at the Category B level. Importantly, in addition, the text includes sections on Public Health Infrastructure, Public Health Law, Surveillance, Mental Health Management and Media Role all of which relate to epidemics of any sort, not just intentional biological events.
Beyond Anthrax: The Weaponization of Infectious Diseases is a product that should serve as a reference point for clinicians, epidemiologists and public health personnel to understand in practical detail many of the aspects of weapons of biowarfare as well as the appropriate responses to them. -
Iron Deficiency and Overload
David I. Mostofsky, Shlomo Yehuda
- Humana Press
- 10 Mars 2010
- 9781597454629
Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.
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Handbook of Drug-Nutrient Interactions
Joseph I. Boullata, Vincent T. Armenti
- Humana Press
- 17 Mars 2010
- 9781603273626
Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.
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Diabetes and Hypertension
George L. Bakris, Samy I. Mcfarlane
- Humana Press
- 19 Octobre 2012
- 9781603273572
Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
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Renal Cell Carcinoma: Clinical Management provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in kidney cancer. The volume reviews new data about risk factors for the disease, profiles the new staging system for renal cell carcinoma (RCC), highlights our current understanding of familial syndromes of RCC and their molecular genetics, and provides new perspectives about imaging of renal tumors. For localized disease, a greater appreciation of nephron-sparing approaches and the importance of preservation of renal function is discussed in detail. Advances in surgical techniques are highlighted. For metastatic disease, the molecular biology of kidney cancer is reviewed in a concise and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. The several landmark phase III targeted therapy trials published in the last few years are placed in context with respect to current management. Integration of surgery and systemic therapy through cytoreductive and consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain are also be discussed.
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Emerging Trends in Cell and Gene Therapy
Ram I. Mahato, Michael K. Danquah
- Humana Press
- 14 Juin 2013
- 9781627034173
Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry. Main features of the book:· Biological aspects of stem cell sources, differentiation and engineering. · Application of microfluidics to study stem cell dynamics· Potential clinical application of stem cells and gene therapy to specific human disease. · Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering. · Biomimetic multiscale topography for cell alignment.
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Neurointervention in the Medical Specialties
Randall C. Edgell, Sean I. Savitz, John Dalfino
- Humana Press
- 26 Novembre 2014
- 9781493919420
Neurointervention in the Medical Specialties is a first-of-its-kind reference that serves as a bridge between the neurointerventionalist and the physicians who most frequently look to these specialists for answers to some of the most intractable problems they face. Providing background on the wide range of diseases treated through neurointervention along with the indications and alternatives to such treatments, this landmark title is grouped into four parts: an introduction to the tools and anatomical structures that are integral to the field; disease processes most often encountered by neurologists, cardiologists, and vascular surgeons; those diseases more frequently treated by neurosurgeons; and finally those diseases first seen by several other specialties including ophthalmologists and head and neck surgeons. Importantly, each chapter includes details of neurointerventional technique and case discussions that are sufficiently detailed to provide a treatment template and guidance to neurointerventionalists in training and practice. At the same time, the descriptions provide referring physicians with insight into how neurointerventional procedures are performed. Finally, there are several concluding, thought-provoking chapters that examine what new opportunities await the field of neurointervention on the horizon. Neurointervention in the Medical Specialties is a major contribution to the literature and invaluable resource for all clinicians and researchers interested in this exciting field.